Cannabis and Osteoporosis
Osteoporosis is a common condition characterized by
decreases in bone mass and microscopic changes in bone architecture. Bone
fractures, especially of the hip and vertebra, are the most common
complications of osteoporosis, often leading to disability and increased
mortality. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269144/)
An understanding of endocannabinoid system regulation of the
skeleton may help patients support endocannabinoid tone in maintaining healthy
bones. Lifestyle choices have significant impact on adult bone mass and the
risk of osteoporosis later in life.
The endocannabinoid system regulates bone development,
growth, and physiology, and is involved in skeletal diseases, such as
osteoporosis. (https://www.ncbi.nlm.nih.gov/pubmed/19634029)
The endocannabinoid system includes CB2 receptors that
encourage the mineralization process that supports strong bones and slows the
creating of new osteoclast cells that control how bone is weakened through the
restoration process. (https://www.researchgate.net/publication/282812369_The_skeletal_endocannabinoid_system_Clinical_and_experimental_insights)
This has been demonstrated in early pre-clinical work on
mouse cells, where beta-caryophyllene stimulated bone marrow cells to
differentiate into osteoblasts that support bone remodeling.
The common terpene found in cannabis, known as
Beta-Caryophyllene, targets CB2 receptors involved in maintaining healthy
bones. In a mouse study, Beta-Caryophyllene enhanced osteoblast mineralization
and suppressed osteoclast formation in mouse cell cultures.
Beta-caryophyllene is a potent CB2 agonist. For oral
administration, enteric coating is required for absorption through the
intestine. 25-50 mg per day of beta-caryophyllene in an enteric oral
formulation is recommended. You may be able to find a cannabis medicine that
offers a high amount of this terpene.
Always talk to a trusted medical professional who understands cannabis, the endocannabinoid system, and your condition, to help guide you on the appropriate medicine.
Information on Cannabis and Osteoporosis was taking from the amazing book
Cannabis Pharmacy: The Practical Guide to Medical Marijuana
By: Michael Backes, fwd by: Andrew Weil, M.D. and edited by
Jack McCue, M.D.
Find it on Amazon here: https://www.amazon.com/Cannabis-Pharmacy-Practical-Medical-Marijuana/dp/031646418X/ref=sr_1_2?ie=UTF8&qid=1541348398&sr=8-2&keywords=cannabis+pharmacy
